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In addition to decreasing the fluidity of the platelet membrane and promoting platelet aggregation, coagulation factors and PAI-1 (plasminogen activator inhibitor-1) will also increase under the condition of hyperglycemia, breaking the balance of coagulation and fibrinolysis and promoting thrombosis

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Wards clustering algorithm and Pearsons distance were applied for the cluster analysis

Optimization of TEAD P-site binding fragment hit into in vivo active lead MSC-4106