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These liver IGF-1-deficient mice were crossed with mice that express a mutant GH that acts as an antagonist, and the resulting mice showed improved insulin sensitivity and decreased blood glucose and insulin levels (175)

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doi: 10.1038/nrrheum.2016.18 120 ZhangB

Careful analyses of trial withdrawal statistics suggest that nausea may in fact be underrecorded, and is strongly associated with treatment discontinuation 67