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The study included patients with HbA1c levels ranging from 7.0-10.0% (53-86 mmol/mol) who were being treated with diet and exercise with or without metformin

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Market Size Estimation and Data Triangulation Bottom-Up Approach The bottom-up approach involved aggregating segment-level data, such as: Company revenues Product-level sales Installed base/usage volumes Adoption and penetration rates Pricing analysis This method was primarily used when detailed micro-level market data were available

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Some wont yet the research is moving faster than the textbooks

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Canagliflozin-treated patients experienced a slower decline in GFR and an 18% reduction in the urea-albumin-creatinine ratio

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In addition, hyperinsulinemia is responsible for the increase in the androgen production through both the direct stimulation of insulin receptors and the cross-reaction with Insulin-like Growth Factor-1 (IGF-1) receptors expressed on thecal cells [14]

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