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Although commenters did not agree with our proposed burden estimate for cost and hours, they did not provide additional information, to include a breakdown of tasks and hours estimates across hospitals, to support a burden estimate revision

Preclinical and Clinical Evidence: Animal Studies vs

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For example, we considered grouping skin substitute products based on their composition (for example, whether they are non-synthetic or synthetic) or by graft type ( e.g., allograft or xenograft)

REDEFINE 1 Phase 3 results (2025