First-in-human trial of the PI3K-selective inhibitor SAR260301 in patients with advanced solid tumors
Here we show that depletion of intracellular GSH does not alter tumour growth and extracellular GSH is highly abundant in the tumour microenvironment, highlighting the potential importance of GSH outside tumours
A 2026 study in Cell Reports Medicine just put it to the test with four preclinical studies and a human clinical trial
Essa Pharma (NASDAQ: EPIX) shares cratered 73% from $5.20 to $1.40 Friday after the company said it was terminating its Phase II trial (NCT05075577) assessing masofaniten combined with enzalutamide vs
doi: 10.1016/j.xphs.2017.02.031
28 (7-8):753-6 Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, and Atsushi Nakajima - Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study - BMC Gastroenterol
