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doi: 10.1186/s12916-025-03919-0

In general, being at a healthy weight equates to a healthier microbiome: Weight loss has been associated with more bacterial diversity and a better balance of good bacteria in the gut

This is the best-case scenario and more common with employer-sponsored plans that have strong pharmacy benefits

Effects on bone may be indirect, mediated through weight loss, changes in calcitonin, or other pathways rather than direct receptor activation in bone tissue

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Hence, DPP-4 inhibitors were developed, as well as several GLP-1 analogs engineered to circumvent DPP-4-mediated breakdown and/or rapid renal elimination