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CRISPRCas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing

Its bi-dimensional nature causes unique interactions with blood proteins and biological membranes that can lead to unusual effects like blood clotting and immune cell activation, when combined with mRNA, lipid nanoparticles, and more

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Thus we have targeted the dimerization process by developing molecules that mimic the dimerization domain, the hinge region, with idea that they can act as dominant negative replacements