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[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management
For the full triple-agonist effect including glucagon-driven fat oxidation, doses of 4mg weekly or higher appear necessary
Results emerge subtly over 48 weeks and can last up to two years or more
The drugs may harness that effect
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