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Developed originally for type 2 diabetes management, semaglutide gained widespread attention after clinical trials revealed that patients were losing significant amounts of weight as a secondary benefit

M.SeilerS.BinderN.EgeP.et al (2012)

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A meta-analysis pooling data from two phase II and five phase III trials 195 confirmed that tirzepatide elicited greater HbA1c reductions than placebo, GLP-1RAs, and basal insulin