doi: 10.21037/atm 93 SuJGaoCXieLFanYShenYHuangQet al
Whereas COX-1 acetylation by aspirin abolishes its enzymatic activity, COX-2 acetylation modifies the enzyme in such a way that it performs an incomplete reaction ultimately resulting in the generation of lipoxins (Claria and Serhan, 1995), which inhibit cancer cell proliferation and angiogenesis (Ferrandez et al, 2012)
The expression of apoptotic signals also appears to be linked to alterations in the GSH pool
The changes in the melanin index, moisture content of the stratum corneum, skin smoothness, skin elasticity and wrinkle formation were objectively assessed
Glutathione inhibits this enzyme, producing less melanin, and the skin becomes light
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