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In the head-to-head SURMOUNT-5 trial (NEJM 2025), tirzepatide produced 20.2% weight loss vs 13.7% for semaglutide

It is a 16-residue peptide encoded not in nuclear DNA but in the mitochondrial 12S rRNA region, placing it in the small class of mitochondrial-derived peptides

Many liquid formulas also need refrigeration after opening, so confirm the storage instructions on the label

Pregnant and breastfeeding women should not use this product without first consulting their doctor

Temperature abuse or improper storage can cause visible degradation days or weeks before the printed expiration date

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