A.ChenM.FalseyJ
Los efectos sobre control glucmico y FRCV asociados a SEMA 2,4mg en el programa STEP son cualitativamente similares, pero cuantitativamente superiores a los observados con LIRA 3mg, en posible relacin con la diferente prdida ponderal16
Previous insulin use and previous glucocorticoid use were identified through redeemed prescriptions (binary variables)
Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks
Liver health markers and insulin sensitivity also improved during treatment
The intervention involved supervised, group-based aerobic and resistance training totaling more than 150 minutes per week at 6085 % of maximum heart rate [6]