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Data from the Semaglutide Treatment Effect in People with Obesity (STEP) trials, which examined the weight loss effects of semaglutide, demonstrated a 3040% reduction in C-reactive protein levels, indicating a significant anti-inflammatory effect

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39,40 Restoration of depleted GSH concentrations in T-cells may be critical for restoration of leukocyte function

However, adverse effects may limit the treatment potential, e.g., glitazones are associated with phenotypical weight gain [136] and obeticholic acid induced pruritus and elevated LDL-C [137], the latter a potential concern in patients already at risk for cardiovascular disease

The bilayer membrane then wraps around the damaged mitochondria