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Adding hexarelin creates chronic receptor saturation that triggers compensatory somatostatin release and blunts future GH pulses
Studies in postmenopausal women have found significantly lower serum antioxidant levels alongside increased markers of oxidative damage compared to premenopausal women
In this setting, mitochondrial ROS from complex I/III sites, NOX2/NOX4 activity in microglia and cerebrovascular endothelium and impaired mitophagy (reduced removal of damaged mitochondria) converge to oxidize proteins and lipids, seed misfolding and aggregation (e.g., -synuclein, A) and blunt synaptic plasticity by altering redox-sensitive receptors, kinases and Ca handling (Lee et al
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