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Lipid liquid-liquid phase separation has also been observed in the membranes of the endoplasmic reticulum upon upregulation of the metabolism of saturated fatty acids, which are amenable to high-density packing (Shen et al., 2017)

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212 FBXO31 enhances cisplatin-induced ferroptosis in cholangiocarcinoma cells and stem cell-like cells, and the mechanism may be related to increased GPX4 ubiquitination and proteasome degradation, which could be reversed by GPX4 overexpression

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Wadden and colleagues assessed changes in depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and suicidal ideation or behaviors using the Columbia Suicide Severity Rating Scale in participants with overweight or obesity using semaglutide 2.4 mg or placebo