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I am back to hiking with my kids on weekends, something that had become difficult when the weight started returning

A 2023 study in Obesity reinforced this, noting that participants on GLP-1s lost significant amounts of fat-free mass if they were not concurrently engaging in resistance training or consuming sufficient dietary protein

In a recent metanalysis of 12 RCTs on the effect of berberine on PCOS patients, it was reported that berberine improved reproductive hormones (TT, SHBG, LH, LH/FSH ratio), lowered fasting and post-prandial blood glucose, and improved lipid profile as compared to placebo/no treatment [13]

However, many retain 30-50% of weight loss long-term if they've established sustained lifestyle changes during treatment

doi: 10.1016/j.molcel.2018.10.042 23 HuangQLeYLiSBianY