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21 In May 2006, House and Senate Small Business Committee chairs posed seven detailed questions to USD (AT&L) on the implementation of new DoD SBIR commercialization initiatives, directing a fresh DoD-wide review of SBIR commercialization with quadrennial follow-up reports to Congress

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That mechanism was validated at meaningful scale: the pivotal trial program supporting FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, one of the larger controlled datasets behind any peptide discussed in this category

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Besides contributing to the increase of tumour mass, the rewiring of cholesterol and sphingolipids metabolism alters the composition of lipid rafts that play an important role in other hallmarks of cancer such as oncogenic signalling, migration, proliferation, adhesion, invasiveness, metastatic spread, apoptosis evasion [51], vesicular trafficking and drug resistance [52]

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