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It does not cover them for weight loss or fatty liver disease, even with prior authorization, because of the statutory exclusion of weight-loss drugs under Medicare Part D (Social Security Act Section 1860D-2(e)(2)(A))

Why it matters: NuSH polyagonists may redefine metabolic careoffering greater reductions in glucose, weight, and liver fat than GLP-1only therapies

Patients with hypothyroidism and certain FTO or MC4R variants often have more aggressive metabolic resistance, meaning they may benefit from higher GLP-1 doses or longer titration schedules

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There is increasing evidence for, and interest in, the concept of 'diabetes remission' using intensive lifestyle interventions early after diagnosis

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