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Actual skin lightening, where your overall complexion becomes noticeably lighter, is less common with topical applications alone

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validation (equal)

These signaling pathways culminate in transcriptional upregulation of pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-), interleukins IL-1 and IL-6, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) [20]