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Efruxifermin Efruxifermin, a bivalent Fc-FGF21 analog developed by Akero Therapeutics, functions as a balanced agonist of FGFR1c, FGFR2c, and FGFR3c through activation of the -Klotho co-receptor

2018 May 3;53:3843

Obesity and meningioma: a US population-based study paired with analysis of a multi-institutional cohort

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Phosphoproteomics results were normalized to the total proteomics

Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15