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In a simian immunodeficiency virus (SIV) model, ATO combined with ART significantly delayed viral rebound post-drug withdrawal, with some monkeys showing no viral rebound after 80 days (compared to 22 days for ART alone)

Functional validation of CYP3A4 activity through rifampicin induction and ketoconazole inhibition demonstrated metabolic competence comparable to existing in vitro liver models, including HepaRG cells and primary human hepatocytes

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Niacin-rich foods include red meat, fish, poultry, nuts, legumes, and eggs

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