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Theyve been around for decades, helping treat patients with type 2 diabetes and short bowel syndrome, but when it was discovered that they could also help patients with obesity, they became several household names Ozempic, Wegovy, Mounjaro, etc

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Essentially, two groups can be distinguished: (i) molecules containing GSH or GSH-like moiety and (ii) molecules whose enzymatic activation occurs through a GSH-conjugate intermediate 109

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Overall, non-presentation of some cell types in such models, the absence of blood flow, and a lack of metabolic and neurochemical coupling between the neuronal cells and the barrier components limit the implication of these models (Bagchi et al., 2019)