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515,516,517 GLP-1 may improve the livers antioxidant capacity and metabolic function by activating Sirt1, thereby helping to alleviate the pathological changes associated with NASH

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Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision

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usually mentioned as mild to moderate and temporary as dose escalation is intended, so in most cases, they are resolved after the maintenance dose is reached (153)