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Uric acidinduced pancreatic -cell dysfunction

Titration strategies, that is, gradually increasing the dose, become more complex when each dose lasts a month

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Cancer-associated adipocytes exhibit phenotypic changes including secretion of the lipids, inflammatory cytokines, and an imbalance in adipokine signaling pathways, such as the upregulation of leptin and downregulation of adiponectin, which promote tumor proliferation and invasion (123)

This case raises important concerns about a possible gastrointestinal adverse effect associated with the use of GLP-1RAs