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In the gastrointestinal tract, COX-1-derived prostaglandins function to increase production of the thick mucus/bicarbonate layer that coats gastric surfaces and buffers them against stomach acid (Vonkeman 2010)

The evidence-based use of thiazide diuretics in hypertension and nephrolithiasis

The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32

In other words, the lower the calcium intake, the higher the risk of developing PIH

It was originally developed to help reduce bleeding by preventing blood clots from breaking down