Dysbiosis is associated with caries, periodontal disease, and (through systemic inflammation) conditions including diabetes and cardiovascular disease
In addition to using genetically engineered bacteria as drug delivery carriers, extracellular vesicles (EVs), especially exocrine bodies, originate from cells through exocytosis and are absorbed by target cells, which can transmit biological signals or even deliver drugs between local or distant cells (47)
Importantly, the causal role of microglia-driven neuroinflammation in tinnitus pathophysiology is most strongly established in noise-induced tinnitus models (Wang et al., 2019
This is why both therapies are often discussed in longevity and performance circles, not as competitors, but as complementary tools
Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb
2005 Aug 1;579(19):4081-7
