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Redox reaction or cleavage of the disulfide bond triggers particle dissociation or aggregation to enhance contrast [98]

Cell culture Erythroid progenitors from SCD patients were generated with peripheral blood mononuclear cells (PBMN) followed by CD34+ cell selection (#17856, StemCell Technologies)

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Collectively, the integrated therapeutic strategies targeting ferroptosis, pyroptosis, and necroptosisincluding RCD inducers combined with ICIs, nanotechnology-driven precision delivery systems, and multi-targeted approaches to overcome metabolic plasticity and off-target toxicitiesprovide a comprehensive framework to enhance melanoma immunotherapy efficacy ( Figure 4 )

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