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Once weight stabilises and the medication is discontinued, the additional GLP-1-driven risk diminishes

That figure is the headline outcome from pharmaceutical-grade retatrutide and is the benchmark against which any non-trial source has to be measured (with the obvious caveat that non-trial sources have no comparable outcome data because they are not run as trials)

In one of the new clinical trials, Wharton and other researchers tested a higher-dose version of the drug, 25 milligrams rather than 14 milligrams, which is the highest dose Rybelsus comes in

For those switching from Zepbound, the average regain was 5.0 kg

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Key Findings from Phase 2 Trials and the Phase 3 Programme Phase 2 data showed approximately 24% mean body weight reduction at the highest dose over 48 weeks