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Rodriguez-Colman MJ, Dansen TB, Burgering BMT (2024) FOXO transcription factors as mediators of stress adaptation

These key studies clearly provided clinical proof-of-concept that blocking the catalytic activity of DPP-4 could be a viable approach to treat T2DM, whilst at the same time helped to allay concern over whether the metabolism of any other potential DPP-4 substrates might be affected to cause unwanted off-target effects

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Tesofensine Peptide works by inhibiting the reuptake of neurotransmitters like dopamine, serotonin, and noradrenaline in the brain