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Significant barriers still exist despite established safety profiles, such as high costs that restrict access worldwide, a lack of predictive biomarkers for treatment response, a lack of knowledge about the mechanistics of gut microbiota interactions, and an incomplete understanding of long-term safety, particularly with regard to thyroid and pancreatic effects

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Two commonly prescribed medications - Gabapentin and Pregabalin (Lyrica) - offer similar benefits but diverge in regard to their pharmacokinetics, side effects, and dosing regimens

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