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Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice

The retroperitoneal collaterals can also form large splenorenal shunts that may decompress the portal system but are associated with severe encephalopathy

While a few non-electrophilic, non-covalent TRPA1 activators are reported (e.g., carvacrol) 4 , only one (PF-4840154) is especially potent 22

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