In addition, long-term use of GLP-1RAs may also have potential safety risks, such as pancreatitis (Shetty et al., 2022) and thyroid diseases ( 6 Discussion T2DM is a chronic disease characterized by hyperglycemia, which eventually leads to microvascular damage and macrovascular events, as well as complications related to peripheral vascular diseases
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Such a multi-electrode arrangement was, for example, used to demonstrate the ability of the cerebellar cortical parallel fiber system to transform sequential inputs to the granule cell layer into synchronous inputs to postsynaptic Purkinje cells [312, 331]
Table of Contents The evolution of GLP-1 therapy into chronic treatment Gastrointestinal tolerability beyond three years Discontinuation trends and persistence patterns Strategies for maintaining long-term GLP-1 safety Clinical implications for chronic therapy The Evolution of GLP-1 Therapy Into Chronic Treatment In the early years of incretin-based therapy, clinicians often viewed GLP-1 receptor agonists as add-on treatments for patients with uncontrolled type 2 diabetes
doi:10.1111/cen.13828 Witchel SF, Teede HJ, Pea AS
New England Journal of Medicine , 375 (4), 311322
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