PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation
Zhang J, Xiang H, Liu J, Chen Y, He R, Liu B
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A Phase IIb trial of mRNA-4157 in combination with pembrolizumab for patients with resected high-risk melanoma showed that this combination therapy prolonged recurrence-free survival compared with pembrolizumab monotherapy and had a manageable safety profile
Neuropsychopharmacology 47 , 309328 (2022)
For a patient weighing which drug to start on, the study offers something no earlier comparison has: a view of what each choice actually buys and what it costs across every outcome that matters, from weight and waistline to muscle, heart, kidneys and how a person feels