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Early surgical intervention when local recurrence is detected enhances survival, because the dismal outcomes are associated with distant metastasis

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Occludin, claudin-5, and claudin-8 were found to be downregulated and redistributed, whereas claudin-2 (pore-forming TJ protein) was strongly upregulated

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[DOI] [PubMed] [Google Scholar] 54.Shaw S, Rubin KP, Lieber CS

Hormones like estrogen and progesterone work hand in hand with the nervous system to manufacture and release brain chemicals called neurotransmitters, which are essential for emotional regulation and mood stabilization