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This benefit was primarily driven by a 29% reduction in hospitalization for heart failure (HR: 0.71

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Genetic and Metabolic Factors That Influence Your Tolerance for Timing Adjustments Individual differences in liver metabolism, kidney clearance, and GLP-1 receptor sensitivity mean that two patients on identical semaglutide doses may experience different tolerability profiles even with the same timing adjustment

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J Pharm Sci 1997;86:1328-33