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However, despite GLP-1 agonists higher efficacy, the higher cost makes them not cost-effective [61] in some analyses when compared to older, less expensive alternatives

Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations

Wegovy works by mimicking a hormone called GLP-1, which targets areas of the brain involved in regulating appetite

Any promotional activity, including so-called awareness campaigns, that functions as a surrogate advertisement for prescription-only drugs shall be viewed seriously and may be treated as irrational or misleading marketing practice, stated Dr Rajeev Singh Raghuvanshi, Drugs Controller General of India

J Diabetes Investig (2010) 1:823

Long-term studies have shown that semaglutide GLP-1 remains effective and safe for weight loss over one to two years