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60 This methodology is of particular interest for rare adverse events that might be challenging to identify in RCT that usually have short follow-up periods and include highly selected populations

Profound sedation, respiratory depression, coma, and death may result from the concomitant use of hydrocodone bitartrate and acetaminophen tablets with benzodiazepines and/or other CNS depressants, including alcohol [e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids]

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Remember, it is vital to read every ingredient on the product label