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As with other medicines in the incretin-based drug class, retatrutide is associated with a range of side effects, the majority of which relate to the gastrointestinal system

This typically resolves quickly

N Engl J Med 358:25602572 The Action to Control Cardiovascular Risk in Diabetes Study Group (2008) Effects of intensive glucose lowering in type 2 diabetes

Researchers are examining retatrutide for its ability to aid weight loss and enhance blood sugar control among individuals with obesity or type 2 diabetes.

A Phase 2a trial specifically examining metabolic dysfunction-associated steatotic liver disease (MASLD) found that retatrutide at 12 mg reduced liver fat by an extraordinary amount, with some participants achieving complete resolution of fatty liver

By altering GLP-1 activity, these drugs help stabilize blood sugar