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The SURMOUNT-1 DXA substudy found that tirzepatide produced a 33.9% reduction in fat mass and a 10.9% reduction in lean mass over 72 weeks, with approximately 75% of total weight lost coming from fat and 25% from lean mass

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Clinical signal to act: When weight loss accelerates and functional strength drops noticeably within 2 to 4 weeks, consult your provider for tailored guidance on medication dose, caloric adjustments, or lab checks