Medical safety (25%): When you don't have a PCP managing your broader health, the quality of medical oversight from your GLP-1 provider matters more
In addition to selling the full semaglutide molecule, the company also markets different parts of the compound, such as individual amino acids and a fatty side chain that can be attached to the peptide to increase the drugs half-life in the body
That eventually manifests as chronic disease
Based on the strength of the clinical data, we expect Wegovy to be added to formularies with utilization management restrictions for prior authorization to prevent off-label use, shorter initial approval periods (e.g., six months approved initially) to ensure efficacy, and quantity limits to reduce stockpiling and waste
The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE/ and LDLr/ Mice by a Mechanism That Includes Inflammatory Pathways. JACC: Basic to Translational Science , vol
However, this approach lacks official recommendations and has not undergone thorough clinical testing to ensure its safety and effectiveness