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The leading theory is that GLP-1s modulate the brains reward pathways

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Concurrently, resistance training directly stimulates the PI3K/Akt/mTOR pathway, promoting muscle protein synthesis and hypertrophy, while also upregulating IRS-1 expression and enhancing insulin sensitivity in muscle (144, 147)

Past research using magnetic resonance imaging (MRI) has supported the importance of hypothalamic activation for sexual arousal in women and men, and PT-141s effectiveness in this regard has been confirmed in studies as well

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This removes a major barrier for patients who avoid needle-based treatments