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Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic joints

Small trials run in a single region, funded or supported by the maker, tend to report larger effects than big independent ones, partly because small studies that happen to land a positive result are the ones that get published while the null ones quietly disappear, and partly because looser blinding and outcome-grading let optimism leak into the numbers

Oxidative stress occurs when there is an imbalance between free radicals (unstable molecules that can damage cells) and antioxidants

Of interest is the strict conservation of the four cysteines (Cys14, Cys47, Cys101 and Cys169) that confer peculiar redox sensitivity to this enzyme

Front Endocrinol 2022

A lack of vitamin B12 can lead to vitamin B12 deficiency anaemia which causes the body to produce abnormally large red blood cells that cannot function properly to carry oxygen around the body, leading to nerve damage or neuropathy