retatrutide clinical trial phase Triple hormone receptor agonist for metabolic dysfunction-associated steatotic liver disease: a randomized 2a When does the first phase

Our goal is to help each patient improve their overall health, mobility, and quality of life through personalized and effective weight management strategies

For cagrilintide vs retatrutide, the following are not established: No direct superiority

Last reviewed: July 2, 2026 Last updated: July 2, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Semaglutide (also injected weekly) reduced body weight by around 11% after 24 to 68 weeks, with effects likely sustained up to two years, drawing on 18 randomized controlled trials (27 949 participants)

Blood pressure recordings were performed by the Telemetry Unit for Cardiovascular Phenotyping at the University of Copenhagen, supported by the Novo Nordisk Foundation (grant number NNF18OC0032728 to M.B.T.)

The drug was also found to slow down the progression of kidney disease in such patients (Marso, Daniels, Brown-Frandsen)