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Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone

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The catalytic efficiency ( k cat / K m ) was obtained by plotting turnover rates (s 1 ) versus substrate concentrations and fitting it to the equation y = catEff x /(1 + Inv K m x (1 + x / K i )), where catEff is the catalytic efficiency and Inv K m is 1/ K m

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Homozygous PRC2 inactivation induces complete loss of trimethylation at lysine 27 of histone 3 (H3K27me3)