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Research consistently shows that resistance training during caloric restriction significantly reduces lean mass loss compared to caloric restriction alone

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Individuals with a history of medullary thyroid cancer, gallbladder disease, pancreatitis, or multiple endocrine neoplasia syndrome type 2 (MEN2) should avoid taking it

doi: 10.1093/jpp/rgaf124 58

The CagriSema metabolic preservation mechanism, specifically the maintenance of mitochondrial function in skeletal muscle during weight loss, could theoretically slow the rate of weight regain by preventing some of the metabolic adaptation that makes regain almost inevitable

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