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Antonina Sidoti, orcid.org/0000-0001-6980-7548 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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This effect has been most extensively studied in individuals with human immunodeficiency virus (HIV)

Risks documented in the literature arise predominantly from unregulated high-dose administration outside clinical settings