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Researchers have shown that interactions between endothelial cells and glial cells can lead to an increase in BBB permeability 177

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Significant pain, spreading redness, warmth, or swelling that worsens over time may indicate infection and warrants medical attention

During this reabsorption process, Urate Transporter 1 (URAT1, encoded by the SLC22A12 gene), located on the brush border of renal tubular epithelial cells, plays the most decisive role, handling about 90% of renal uric acid reabsorption [12-13]