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Beyond T2DM, the Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes trial is assessing whether GLP-1 RAs can meaningfully reduce MACE, HF hospitalizations, and other cardiovascular endpoints in patients with type 1 diabetes, a population generally underrepresented in cardiovascular prevention studies [66]

Dosing schedules differ between formulations : Ozempic (for type 2 diabetes): Typically starts at 0.25 mg weekly for 4 weeks, increases to 0.5 mg, with potential further increases to 1 mg or 2 mg based on glycaemic response Wegovy (for weight management): Follows a 5-step dose escalation0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg weekly, with each step typically lasting 4 weeks This gradual approach allows the body to adapt to the medication's effects and helps minimise gastrointestinal side effects

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doi: 10.1016/j.bcp.2020.114187, 130 SanfordM

Extracellular amyloid deposits in alzheimers and creutzfeldtjakob disease: similar behavior of different proteins