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If the patients gonads do not produce enough or indeed any hormones or after a gonadectomy has been performed, sexual hormone treatment become necessary [151] at the appropriate time, as already detailed in the Part 1 of these guidelines [13]

Insulin growth factor 1 receptor-mediated pro-oncogenic signaling has been demonstrated in multiple cancers and molecular mechanisms leading to dysregulation of IGF-1R has been an intense focus of cancer research