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Higher mortality among lean patients with non-alcoholic fatty liver disease despite fewer metabolic comorbidities

These effects become therapeutically interesting in obesity because they suggest that glucagon receptor activation could complement appetite suppression by increasing caloric expenditure and improving hepatic lipid handling

At 48 weeks, the 12 mg dose achieved about 24 percent weight reduction

Most patients find symptoms fade as the body adapts

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Eli Lilly noted that discontinuation rates were highly correlated with baseline BMI, with participants who had lower baseline BMI more likely to discontinue due to excessive weight loss